small-molecule senolytic drugs Search Results


small-molecule senolytic drugs  (SCAPS GmbH)
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SCAPS GmbH small-molecule senolytic drugs
Immunotherapy targeting SCs. ( A ) <t>Senolytic</t> CAR T cells. Senolytic CAR T cells express chimeric receptors targeting specific antigens in SCs. ( B ) Immune checkpoint blockade (ICB). Anti-PD-1/PD-L1 antibodies attenuate the inhibitory signaling of PD-L1 + SCs to T cells, reactivate immune surveillance, and activate T cells to clear SCs. ( C ) Senolytic vaccination. After the injection of the senolytic vaccine, the antibodies produced by this vaccine bind only to senoantigen on the surface of SCs, thereby labeling the SCs and inducing antibody-dependent cell-mediated cytotoxicity (ADCC) to kill these SCs. Created with BioRender.com (accessed on 10 May 2024).
Small Molecule Senolytic Drugs, supplied by SCAPS GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/small-molecule+senolytic+drugs/pmc11987807-46-6-17?v=SCAPS+GmbH
Average 90 stars, based on 1 article reviews
small-molecule senolytic drugs - by Bioz Stars, 2026-08
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Immunotherapy targeting SCs. ( A ) Senolytic CAR T cells. Senolytic CAR T cells express chimeric receptors targeting specific antigens in SCs. ( B ) Immune checkpoint blockade (ICB). Anti-PD-1/PD-L1 antibodies attenuate the inhibitory signaling of PD-L1 + SCs to T cells, reactivate immune surveillance, and activate T cells to clear SCs. ( C ) Senolytic vaccination. After the injection of the senolytic vaccine, the antibodies produced by this vaccine bind only to senoantigen on the surface of SCs, thereby labeling the SCs and inducing antibody-dependent cell-mediated cytotoxicity (ADCC) to kill these SCs. Created with BioRender.com (accessed on 10 May 2024).

Journal: Cells

Article Title: Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies

doi: 10.3390/cells14070499

Figure Lengend Snippet: Immunotherapy targeting SCs. ( A ) Senolytic CAR T cells. Senolytic CAR T cells express chimeric receptors targeting specific antigens in SCs. ( B ) Immune checkpoint blockade (ICB). Anti-PD-1/PD-L1 antibodies attenuate the inhibitory signaling of PD-L1 + SCs to T cells, reactivate immune surveillance, and activate T cells to clear SCs. ( C ) Senolytic vaccination. After the injection of the senolytic vaccine, the antibodies produced by this vaccine bind only to senoantigen on the surface of SCs, thereby labeling the SCs and inducing antibody-dependent cell-mediated cytotoxicity (ADCC) to kill these SCs. Created with BioRender.com (accessed on 10 May 2024).

Article Snippet: Later, it was discovered that some small-molecule senolytic drugs that target proteins in senescent cell antiapoptotic pathways (SCAPs) can selectively kill SCs ( ) [ , ].

Techniques: Injection, Produced, Labeling